Compared with the traditional three-section current protection,the current differential protection can improve the protection performance as a whole in the active distribution network,but reduce the wide coverage of fibre channel . The 5G,with its advantages of high reliability,low latency and wide coverage,is expected to become a new communication scheme for differential protection in active distribution network. However,the 5G communication may still be affected by environmental interference and other factors,resulting in the missing of sampling data,which may affect the correct operation of the protection under the normal operation and external fault scenarios. To solve the above problems,firstly,combined with the ρ plane method,the influences of various sampling data missing scenarios on the protection operation are analyzed qualitatively. Then,a strategy to reconstruct the missing sampling data by using order combination Neville interpolation method is proposed. Finally,an active distribution network simulation model is built in PSCAD,and the interpolation precisions of various interpolation methods are compared under a variety of missing sampling data scenarios,which verifies the effectiveness of the strategy proposed in this paper for improving the protection operation characteristics. Through theoretical calculation and analysis,it is concluded that the proposed strategy does not affect the real-time performance of protection in high-performance central processing unit (CPU).