In order to find the reasons why the wind vibration effect of the large single-pile offshore wind power installation is more significant, the pile-soil interaction of the structure is considered using the p-y curve, the principle and characteristics of the wind-structure fluid-structure coupling are theoretically analyzed. The numerical model of the "wind wheel-cabin-tower-foundation" machine model is established by the ADINA software and used to simulate the wind-induced vibration of the whole machine model. The comparative analysis with the on-site monitoring data shows that the numerical modal analysis and field monitoring results is relatively consistent. The numerical analysis of the dynamic response of the wind-induced wind turbine structure considering the fluid-solid coupling effect is close to the on-site monitoring vibration results, and the trend is consistent. The research results show that the whole machine numerical model and the numerical wind tunnel proposed in this paper are reliable and feasible for wind vibration analysis of the whole wind turbine structure, which provides a scientific basis for the structural design and vibration control simulation research of wind power installations, and have certain reference for wind vibration analysis of similar engineering structures.