With the increasing scale of the distribution network, the increasing load of electricity, the three-phase load imbalance seriously affected the stable operation of the power grid. Not only distribution network loss increases, power quality are also reduced. The relationship between the three-phase unbalance and the increase rate of the line loss is deduced, which not only considers the asymmetry of the three-phase current, but also analyzes the influence of the phase. The relationship between unbalanced-distribution load-voltage offset is analyzed comprehensively, and the method of warning of voltage offset based on unbalance index is proposed. Results show that the three-phase imbalance has certain impact on the line loss increase rate and voltage offset, and the correlation cannot be neglected, combined with the specific engineering example of Huangdao area and above derivation formulas. It can provide reference for the operation decision of distribution system and have positive effect on the improvement of power supply quality of distribution network.